CovidV2, Main, Exploration, bibRecord, 001537

Cis-acting RNA elements in human and animal plus-strand RNA viruses

Identifieur interne : 001537 ( Main/Exploration ); précédent : 001536; suivant : 001538

Cis-acting RNA elements in human and animal plus-strand RNA viruses

Auteurs : Ying Liu ; Eckard Wimmer ; Aniko V. Paul

Source :

Biochimica et biophysica acta [ 0006-3002 ] ; 2009.

RBID : PMC:2783963

Abstract

The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions. Those structures that are functionally important are called cis-acting RNA elements because their functions cannot be complemented in trans. They can be involved not only in RNA/RNA interactions but also in binding of viral and cellular proteins during the complex processes of translation, RNA replication and encapsidation. Most viral cis-acting RNA elements are located in the highly structured 5′- and 3′-nontranslated regions of the genomes but sometimes they also extend into the adjacent coding sequences. In addition, some cis-acting RNA elements are embedded within the coding sequences far away from the genomic ends. Although the functional importance of many of these structures have been confirmed by genetic and biochemical analyses their precise roles are not yet fully understood. In this review we have summarized what is known about cis-acting RNA elements in nine families of human and animal plus-strand RNA viruses with an emphasis on the most thoroughly characterized virus families, the Picornaviridae and Flaviviridae.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783963

DOI: 10.1016/j.bbagrm.2009.09.007
PubMed: 19781674
PubMed Central: 2783963

Affiliations:

Le document en format XML

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-acting RNA elements in human and animal plus-strand RNA viruses</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">The RNA genomes of plus-strand RNA viruses have the ability to form secondary and higher-order structures that contribute to their stability and to their participation in inter- and intramolecular interactions. Those structures that are functionally important are called <italic>cis</italic>
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Cis-acting RNA elements in human and animal plus-strand RNA viruses

Cis-acting RNA elements in human and animal plus-strand RNA viruses

Source :

Abstract

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Le document en format XML

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